The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1.
نویسندگان
چکیده
A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.
منابع مشابه
Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1† †Electronic supplementary information (ESI) available: Full experimental details for the synthesis, characterisation, testing and analysis of 16, with characterisation data for 17. See DOI: 10.1039/b818606e Click here for additional data file.
Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 18 شماره
صفحات -
تاریخ انتشار 2009